Sample size using mean squared error (MSE)
It calculates sample size for the bioequivalence test on ratio using mean squared error (MSE).
ssmse(mse, DesignNo = 1, True.R = 1, Alpha = 0.1, Beta = 0.2,
ThetaL = 0.8, ThetaU = 1.25, nMax = 999999)mse |
Mean squared error |
DesignNo |
Crossover design number.
Design Number (treatment x sequence x period)
1 2x2x2 : RT TR (no carry-over)
2 2x4x2 (Balaam Design) : TT RR RT TR (no carry-over)
3 2x2x3 (Two-sequence Dual Design): TRR RTT (no carry-over)
4 2x3x3 : TRR RTR RRT - carry-over effect
5 2x2x4c : TRRT RTTR + carry-over effect
6 2x2x4 : TRRT RTTR - carry-over effect
7 2x4x4 : TTRR RRTT TRRT RTTR
8 3x6x3c (William Design for 3 treatments) + carry-over effect
: RBA ARB BAR ABR BRA RAB
9 3x6x3 (William Design for 3 treatments) - carry-over effect
: RBA ARB BAR ABR BRA RAB
10 4x4x4c (William Design for 4 treatments) + carry-over effect
: RCAB ARBC BACR CBRA
11 4x4x4 (William Design for 4 treatments) - carry-over effect
: RCAB ARBC BACR CBRA
|
True.R |
True ratio of test/reference |
Alpha |
Alpha error level |
Beta |
Beta error level |
ThetaL |
Lower limit of equivalence criteria |
ThetaU |
Upper limit of equivalence criteria |
nMax |
Maximum subject number (sample size) per group |
It calculates sample size (n per group) with mse, Alpha, and Beta for bioequivalence test.
Returns sample size (n per group) for bioequivalence test with ratio criteria.
Kyun-Seop Bae k@acr.kr
ssmse(0.06)
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