Calculate Graffelman-Weir exact density for bi-allelic X-chromosomal variant
Function dgraffelmanweir calculate the probability P(NAB=nab and
MA=ma|NA=na) for a bi-allelic X-chromosomal variant.
dgraffelmanweir.bi(x, y)
x |
vector with male genotype counts (A,B) |
y |
vector with female genotype counts (AA,AB,BB) |
a single real number
Jan Graffelman jan.graffelman@upc.edu
Graffelman, J. and Weir, B.S. (2016) Testing for Hardy-Weinberg equilibrium at bi-allelic genetic markers on the X chromosome. Heredity 116(6) pp. 558–568. doi: 10.1038/hdy.2016.20
males <- c(A=392, B=212) females <- c(AA=275, AB=296, BB=80) prob <- dgraffelmanweir.bi(males,females) print(prob)
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