Data set: Support vector machines and neural networks applied to the prediction of HIV-1 coreceptor usage
Linear support vector machines (libsvm) and neural networks (R package nnet) were applied to predict usage of the coreceptors CCR5 and CXCR4 based on sequence data of the third variable loop of the HIV envelope protein.
data(ROCR.hiv)
A list consisting of the SVM (ROCR.hiv$hiv.svm
) and NN
(ROCR.hiv$hiv.nn
) classification data. Each of those is in turn a list
consisting of the two elements $predictions
and $labels
(10
element list representing cross-validation data).
Sing, T. & Beerenwinkel, N. & Lengauer, T. "Learning mixtures of localized rules by maximizing the area under the ROC curve". 1st International Workshop on ROC Analysis in AI, 89-96, 2004.
library(ROCR) data(ROCR.hiv) attach(ROCR.hiv) pred.svm <- prediction(hiv.svm$predictions, hiv.svm$labels) pred.svm perf.svm <- performance(pred.svm, 'tpr', 'fpr') perf.svm pred.nn <- prediction(hiv.nn$predictions, hiv.svm$labels) pred.nn perf.nn <- performance(pred.nn, 'tpr', 'fpr') perf.nn plot(perf.svm, lty=3, col="red",main="SVMs and NNs for prediction of HIV-1 coreceptor usage") plot(perf.nn, lty=3, col="blue",add=TRUE) plot(perf.svm, avg="vertical", lwd=3, col="red", spread.estimate="stderror",plotCI.lwd=2,add=TRUE) plot(perf.nn, avg="vertical", lwd=3, col="blue", spread.estimate="stderror",plotCI.lwd=2,add=TRUE) legend(0.6,0.6,c('SVM','NN'),col=c('red','blue'),lwd=3)
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