coloc: sdY.est – R documentation

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sdY.est

Estimate trait variance, internal function

Description

Estimate trait standard deviation given vectors of variance of coefficients, MAF and sample size

Usage

sdY.est(vbeta, maf, n)

Arguments

`vbeta`	vector of variance of coefficients
`maf`	vector of MAF (same length as vbeta)
`n`	sample size

Details

Estimate is based on var(beta-hat) = var(Y) / (n * var(X)) var(X) = 2*maf*(1-maf) so we can estimate var(Y) by regressing n*var(X) against 1/var(beta)

Value

estimated standard deviation of Y

Author(s)

Chris Wallace

coloc

Colocalisation Tests of Two Genetic Traits

v3.2-1

GPL

Authors

Chris Wallace [aut, cre], Claudia Giambartolomei [aut], Vincent Plagnol [ctb]

Initial release

2019-05-16