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ccl4data

Closed Chamber Study of CCl4 Metabolism by Rats.

Description

The results of a closed chamber experiment to determine metabolic parameters for CCl4 (carbon tetrachloride) in rats.

Usage

data(ccl4data)

Format

This data frame contains the following columns:

time

the time (in hours after starting the experiment).

initconc

initial chamber concentration (ppm).

animal

this is a repeated measures design; this variable indicates which animal the observation pertains to.

ChamberConc

chamber concentration at time, in ppm.

Source

Evans, et al. 1994 Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicology and Applied Pharmacology 128: 36 – 44.

Examples

plot(ChamberConc ~ time, data = ccl4data, xlab = "Time (hours)",
  xlim = range(c(0, ccl4data$time)),
  ylab = "Chamber Concentration (ppm)", log = "y")
ccl4data.avg <- aggregate(ccl4data$ChamberConc,
                  by = ccl4data[c("time", "initconc")], mean)
points(x ~ time, data = ccl4data.avg, pch = 16)
deSolve

Solvers for Initial Value Problems of Differential Equations ('ODE', 'DAE', 'DDE')

v1.28
GPL (>= 2)
Authors
Karline Soetaert [aut] (<https://orcid.org/0000-0003-4603-7100>), Thomas Petzoldt [aut, cre] (<https://orcid.org/0000-0002-4951-6468>), R. Woodrow Setzer [aut] (<https://orcid.org/0000-0002-6709-9186>), Peter N. Brown [ctb] (files ddaspk.f, dvode.f, zvode.f), George D. Byrne [ctb] (files dvode.f, zvode.f), Ernst Hairer [ctb] (files radau5.f, radau5a), Alan C. Hindmarsh [ctb] (files ddaspk.f, dlsode.f, dvode.f, zvode.f, opdkmain.f, opdka1.f), Cleve Moler [ctb] (file dlinpck.f), Linda R. Petzold [ctb] (files ddaspk.f, dlsoda.f), Youcef Saad [ctb] (file dsparsk.f), Clement W. Ulrich [ctb] (file ddaspk.f)
Initial release

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