drc: CRS.5a – R documentation

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CRS.5a

Cedergreen-Ritz-Streibig dose-reponse model for describing hormesis

Description

'CRS.5a', 'CRS.5b' and 'CRS.5c' provide the Cedergreen-Ritz-Streibig modified log-logistic model for describing (inverse u-shaped or j-shaped) hormesis.

'UCRS.5a', 'UCRS.5b' and 'UCRS.5c' provide the Cedergreen-Ritz-Streibig modified log-logistic model for describing u-shaped hormesis.

Usage

CRS.5a(names = c("b", "c", "d", "e", "f"), ...)

  UCRS.5a(names = c("b", "c", "d", "e", "f"), ...)

Arguments

`names`	a vector of character strings giving the names of the parameters.
`...`	additional arguments to be passed from the convenience functions.

Details

The model function for inverse u-shaped hormetic patterns is

f(x) = c + \frac{d-c+f \exp(-1/x^{α})}{1+\exp(b(\log(x)-\log(e)))}

which is a five-parameter model. It is a modification of the four-parameter log-logistic curve to take hormesis into account.

The parameters have the following interpretations

b: Not direct interpretation
c: Lower horizontal asymptote
d: Upper horizontal asymptote
e: Not direct interpretation
f: Size of the hormesis effect: the larger the value the larger is the hormesis effect. f=0 corresponds to no hormesis effect and the resulting model is the four-parameter log-logistic model. This parameter should be positive in order for the model to make sense.

The model function for u-shaped hormetic patterns is

f(x) = c + d - \frac{d-c+f \exp(-1/x^{α})}{1+\exp(b(\log(x)-\log(e)))}

This model also simplifies to the four-parameter log-logistic model in case f=0 (in a slightly different parameterization as compared to the one used in LL.4).

The models denoted a,b,c are obtained by fixing the alpha parameter at 1, 0.5 and 0.25, respectively.

Value

See cedergreen.

Note

This function is for use with the function drm.

Author(s)

Christian Ritz

References

See the reference under cedergreen.

Examples

## Modified logistic model
lettuce.m1 <- drm(lettuce[,c(2,1)], fct=CRS.5a())
summary(lettuce.m1)
ED(lettuce.m1, c(50))

lettuce.m2 <- drm(lettuce[,c(2,1)], fct=CRS.5b())
summary(lettuce.m2)
ED(lettuce.m2, c(50))

lettuce.m3 <- drm(lettuce[,c(2,1)], fct=CRS.5c())
summary(lettuce.m3)
ED(lettuce.m3, c(50))

drc

Analysis of Dose-Response Curves

v3.0-1

GPL-2 | file LICENCE

Authors

Christian Ritz <ritz@bioassay.dk>, Jens C. Strebig <streibig@bioassay.dk>

Initial release

2016-08-25