drc: P.promelas – R documentation

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P.promelas

Effect of sodium pentachlorophenate on growth of fathead minnow

Description

Fathead minnows (Pimephales promelas) were exposed to sodium pentachlorophenate concentrations ranging from 32 to 512 micro g/L in a 7-day larval survival and growth test. The average dry weight was measured.

Usage

data(P.promelas)

Format

A data frame with 24 observations on the following 2 variables.

conc: a numeric vector of sodium pentachlorophenate concentrations (micro g/L).
dryweight: a numeric vector dry weights (mg)

Details

The data are analysed in Bruce and Versteeg (1992) using a log-normal dose-response model (using the logarithm with base 10).

Source

Bruce, R. D. and Versteeg, D. J. (1992) A statistical procedure for modeling continuous toxicity data, Environ. Toxicol. Chem., 11, 1485–1494.

Examples

## Model with ED50 on log scale as parameter
p.prom.m1<-drm(dryweight~conc, data=P.promelas, fct=LN.3())

plot(fitted(p.prom.m1), residuals(p.prom.m1))

plot(p.prom.m1, type="all", broken=TRUE, xlim=c(0,1000))
summary(p.prom.m1)
ED(p.prom.m1, c(10,20,50), interval="delta")

## Model with ED50 as parameter
p.prom.m2<-drm(dryweight~conc, data=P.promelas, fct=LN.3(loge=TRUE))
summary(p.prom.m2)
ED(p.prom.m2, c(10,20,50), interval="fls")

drc

Analysis of Dose-Response Curves

v3.0-1

GPL-2 | file LICENCE

Authors

Christian Ritz <ritz@bioassay.dk>, Jens C. Strebig <streibig@bioassay.dk>

Initial release

2016-08-25