drc: neill.test – R documentation

Become an expert in R — Interactive courses, Cheat Sheets, certificates and more!

neill.test

Neill's lack-of-fit test for dose-response models

Description

'neill.test' provides a lack-of-fit test for non-linear regression models. It is applicable both in cases where there are replicates (in which case it reduces to the standard lack-of-fit test against an ANOVA model) and in cases where there are no replicates, though then a grouping has to be provided.

Usage

neill.test(object, grouping, method = c("c-finest", "finest", "percentiles"), 
  breakp = NULL, display = TRUE)

Arguments

`object`	object of class 'drc' or 'nls'.
`grouping`	character or numeric vector that provides the grouping of the dose values.
`method`	character string specifying the method to be used to generate a grouping of the dose values.
`breakp`	numeric vector of break points for generating dose intervals that form a grouping.
`display`	logical. If TRUE results are displayed. Otherwise they are not (useful in simulations).

Details

The functions used the methods df.residual and residuals and the 'data' component of object (only for determining the number of observations).

Value

The function returns an object of class anova which is displayed using print.anova.

Note

A clustering technique could be employed to determine the grouping to be used in cases where there are no replicates. There should at most be ceiling(n/2) clusters as otherwise some observations will not be used in the test. At the other end there need to be more clusters than parameters in the model.

Author(s)

Christian Ritz

References

Neill, J. W. (1988) Testing for lack of fit in nonlinear regression, Ann. Statist., 16, 733–740

Examples

### Example with 'drc' object

## Lack-of-fit test against ANOVA
ryegrass.m1 <-drm(rootl~conc, data = ryegrass, fct = LL.4())
modelFit(ryegrass.m1)

## The same test using 'neill.test'
neill.test(ryegrass.m1, ryegrass$conc)

## Generating a grouping
neill.test(ryegrass.m1, method="c-finest")
neill.test(ryegrass.m1, method="finest")
neill.test(ryegrass.m1, method="perc")

drc

Analysis of Dose-Response Curves

v3.0-1

GPL-2 | file LICENCE

Authors

Christian Ritz <ritz@bioassay.dk>, Jens C. Strebig <streibig@bioassay.dk>

Initial release

2016-08-25