Compute Empirical Higher Criticism Scores and Corresponding Decision Threshold From p-Values
hc.score computes the empirical higher criticism (HC) scores from p-values.
hc.thresh determines the HC decision threshold by searching for the p-value with the maximum HC score.
hc.score(pval) hc.thresh(pval, alpha0=1, plot=TRUE)
pval |
vector of p-values. |
alpha0 |
look only at a fraction |
plot |
show plot with HC decision threshold. |
Higher Criticism (HC) provides an alternative means to determine decision thresholds for signal identification, especially if the signal is rare and weak.
See Donoho and Jin (2008) for details of this approach and Klaus and Strimmer (2012) for a review and connections with FDR methdology.
hc.score returns a vector with the HC score corresponding to each p-value.
hc.thresh returns the p-value corresponding to the maximum HC score.
Bernd Klaus and Korbinian Strimmer (http://www.strimmerlab.org).
Donoho, D. and J. Jin. (2008). Higher criticism thresholding: optimal feature selection when useful features are rare and weak. Proc. Natl. Acad. Sci. USA 105:14790-15795.
Klaus, B., and K. Strimmer (2013). Signal identification for rare and weak features: higher criticism or false discovery rates? Biostatistics 14: 129-143. <DOI:10.1093/biostatistics/kxs030>
# load "fdrtool" library
library("fdrtool")
# some p-values
data(pvalues)
# compute HC scores
hc.score(pvalues)
# determine HC threshold
hc.thresh(pvalues)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.