Mayo Clinic primary biliary cirrhosis data
This data is from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of 424 PBC patients, referred to Mayo Clinic during that ten-year interval met eligibility criteria for the randomized placebo controlled trial of the drug D-penicillamine, but only the first 312 cases in the data set participated in the randomized trial. Therefore, the data here are for the 312 patients with largely complete data.
data(pbc2)
A data frame with 1945 observations on the following 20 variables:
idpatients identifier; in total there are 312 patients.
yearsnumber of years between registration and the earlier of death, transplantation, or study analysis time.
statusa factor with levels alive, transplanted
and dead.
druga factor with levels placebo and
D-penicil.
ageat registration in years.
sexa factor with levels male and female.
yearnumber of years between enrollment and this visit date, remaining values on the line of data refer to this visit.
ascitesa factor with levels No and Yes.
hepatomegalya factor with levels No and Yes.
spidersa factor with levels No and Yes.
edemaa factor with levels No edema (i.e. no edema and
no diuretic therapy for edema), edema no diuretics (i.e. edema
present without diuretics, or edema resolved by diuretics), and
edema despite diuretics (i.e. edema despite diuretic therapy).
serBilirserum bilirubin in mg/dl.
serCholserum cholesterol in mg/dl.
albuminalbumin in mg/dl.
alkalinealkaline phosphatase in U/liter.
SGOTSGOT in U/ml.
plateletsplatelets per cubic ml/1000.
prothrombinprothrombin time in seconds.
histologichistologic stage of disease.
status2a numeric vector with the value 1 denoting if the patient was dead, and 0 if the patient was alive or transplanted.
Fleming T, Harrington D. Counting Processes and Survival Analysis. 1991; New York: Wiley.
Therneau T, Grambsch P. Modeling Survival Data: Extending the Cox Model. 2000; New York: Springer-Verlag.
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