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maftools

compareSignatures

Compares identified denovo mutational signatures to known COSMIC signatures

Description

Takes results from extractSignatures and compares them known COSMIC signatures. Two COSMIC databases are used for comparisons - "legacy" which includes 30 signaures, and "SBS" - which includes updated/refined 65 signatures

Usage

compareSignatures(nmfRes, sig_db = "legacy", verbose = TRUE)

Arguments

nmfRes

results from extractSignatures
sig_db

can be legacy or SBS. Default legacy
verbose

Default TRUE

Details

SBS signature database was obtained from https://www.synapse.org/#!Synapse:syn11738319.7

Value

list containing cosine smilarities, aetiologies if available, and best match.

See Also

maftools

Summarize, Analyze and Visualize MAF Files

v2.6.05
MIT + file LICENSE
Authors
Anand Mayakonda [aut, cre] (<https://orcid.org/0000-0003-1162-687X>)
Initial release
2015-12-14

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