Chronic Myelogenous Leukemia survival data.
Survival in a randomised trial comparing three treatments for Chronic Myelogeneous Leukemia (simulated data).
data("cml")A data frame with 507 observations on the following 7 variables.
centera factor with 54 levels indicating the study center.
treatmenta factor with levels trt1, trt2, trt3 indicating the treatment group.
sexsex (0 = female, 1 = male)
ageage in years
riskgrouprisk group (0 = low, 1 = medium, 2 = high)
statuscensoring status (FALSE = censored, TRUE = dead)
timesurvival or censoring time in days.
The data are simulated according to structure of the data by the German CML Study Group used in Hehlmann (1994).
R. Hehlmann, H. Heimpel, J. Hasford, H.J. Kolb, H. Pralle, D.K. Hossfeld, W. Queisser, H. Loeffler, A. Hochhaus, B. Heinze (1994), Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML study group. Blood 84(12):4064-4077.
if (require("coxme")) {
data("cml")
### one-sided simultaneous confidence intervals for many-to-one
### comparisons of treatment effects concerning time of survival
### modeled by a frailty Cox model with adjustment for further
### covariates and center-specific random effect.
cml_coxme <- coxme(Surv(time, status) ~ treatment + sex + age + riskgroup + (1|center),
data = cml)
glht_coxme <- glht(model = cml_coxme, linfct = mcp(treatment = "Dunnett"),
alternative = "greater")
ci_coxme <- confint(glht_coxme)
exp(ci_coxme$confint)[1:2,]
}Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.