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dot-rxGenEBE

Generate pieces for EBE only problem


Description

Generate pieces for EBE only problem

Usage

.rxGenEBE(
  obj,
  predfn,
  pkpars = NULL,
  errfn = NULL,
  init = NULL,
  pred.minus.dv = TRUE,
  sum.prod = FALSE,
  optExpression = TRUE,
  theta = FALSE,
  addProp = c("combined2", "combined1")
)

Arguments

obj

RxODE object

predfn

Prediction function

pkpars

Pk Pars function

errfn

Error function

init

Initialization parameters for scaling.

pred.minus.dv

Boolean stating if the FOCEi objective function is based on PRED-DV (like NONMEM). Default TRUE.

sum.prod

A boolean determining if RxODE should use more numerically stable sums/products.

optExpression

Optimize the model text for computer evaluation.

theta

Calculate THETA derivatives instead of ETA derivatives. By default FALSE

addProp

one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem:

combined1: transform(y)=transform(f)+(a+b*f^c)*eps

combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps

Value

RxODE/symengine environment

Author(s)

Matthew L. Fidler


RxODE

Facilities for Simulating from ODE-Based Models

v1.0.9
GPL (>= 3)
Authors
Matthew L. Fidler [aut] (<https://orcid.org/0000-0001-8538-6691>), Melissa Hallow [aut], Wenping Wang [aut, cre], Zufar Mulyukov [ctb], Alan Hindmarsh [ctb], Awad H. Al-Mohy [ctb], Matt Dowle [ctb], Cleve Moler [ctb], David Cooley [ctb], Drew Schmidt [ctb], Arun Srinivasan [ctb], Ernst Hairer [ctb], Gerhard Wanner [ctb], Goro Fuji [ctb], Hadley Wickham [ctb], Jack Dongarra [ctb], Linda Petzold [ctb], Martin Maechler [ctb], Matteo Fasiolo [ctb], Morwenn [ctb], Nicholas J. Higham [ctb], Roger B. Sidje [ctb], Simon Frost [ctb], Kevin Ushey [ctb], Yu Feng [ctb]
Initial release

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