Generate the d(err)/d(eta) values for FO related methods
Generate the d(err)/d(eta) values for FO related methods
.rxGenHdEta(
obj,
predfn,
pkpars = NULL,
errfn = NULL,
init = NULL,
pred.minus.dv = TRUE,
promoteLinSens = TRUE,
theta = FALSE,
addProp = c("combined2", "combined1")
)obj |
RxODE object |
predfn |
Prediction function |
pkpars |
Pk Pars function |
errfn |
Error function |
init |
Initialization parameters for scaling. |
pred.minus.dv |
Boolean stating if the FOCEi objective function is based on PRED-DV (like NONMEM). Default TRUE. |
promoteLinSens |
Promote solved linear compartment systems to sensitivity-based solutions. |
theta |
Calculate THETA derivatives instead of ETA derivatives. By default FALSE |
addProp |
one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem: combined1: transform(y)=transform(f)+(a+b*f^c)*eps combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps |
RxODE/symengine environment
Matthew L. Fidler
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