Description

This calculates the derived parameters based on what is provided in a data frame or arguments

Usage

Arguments

Value

Return a data.frame of derived PK parameters for a 1-, 2-, or 3-compartment linear model given provided clearances and volumes based on the inferred model type.

The model parameters that will be provided in the data frame are:

• vc: Central Volume (for 1-, 2- and 3- compartment models)

• kel: First-order elimination rate (for 1-, 2-, and 3-compartment models)

• k12: First-order rate of transfer from central to first peripheral compartment; (for 2- and 3-compartment models)

• k21: First-order rate of transfer from first peripheral to central compartment, (for 2- and 3-compartment models)

• k13: First-order rate of transfer from central to second peripheral compartment; (3-compartment model)

• k31: First-order rate of transfer from second peripheral to central compartment (3-compartment model)

• vp: Peripheral Volume (for 2- and 3- compartment models)

• vp2: Peripheral Volume for 3rd compartment (3- compartment model)

• vss: Volume of distribution at steady state; (1-, 2-, and 3-compartment models)

• t12alpha: t_{1/2,α}; (1-, 2-, and 3-compartment models)

• t12beta: t_{1/2,β}; (2- and 3-compartment models)

• t12gamma: t_{1/2,γ}; (3-compartment model)

• alpha: α; (1-, 2-, and 3-compartment models)

• beta: β; (2- and 3-compartment models)

• gamma: β; (3-compartment model)

• A: true A; (1-, 2-, and 3-compartment models)

• B: true B; (2- and 3-compartment models)

• C: true C; (3-compartment model)

• fracA: fractional A; (1-, 2-, and 3-compartment models)

• fracB: fractional B; (2- and 3-compartment models)

• fracC: fractional C; (3-compartment model)

Author(s)

Matthew Fidler and documentation from Justin Wilkins, justin.wilkins@occams.com

References

Shafer S. L. CONVERT.XLS

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Clipping Williams & Wilkins, Philadelphia, 2010.

Examples