nlme: phenoModel – R documentation

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phenoModel

Model function for the Phenobarb data

Description

A model function for a model used with the Phenobarb data. This function uses compiled C code to improve execution speed.

Usage

phenoModel(Subject, time, dose, lCl, lV)

Arguments

`Subject`	an integer vector of subject identifiers. These should be sorted in increasing order.
`time`	numeric. A vector of the times at which the sample was drawn or the drug administered (hr).
`dose`	numeric. A vector of doses of drug administered (μg/kg).
`lCl`	numeric. A vector of values of the natural log of the clearance parameter according to `Subject` and `time`.
`lV`	numeric. A vector of values of the natural log of the effective volume of distribution according to `Subject` and `time`.

Details

See the details section of Phenobarb for a description of the model function that phenoModel evaluates.

Value

a numeric vector of predicted phenobarbital concentrations.

Author(s)

José Pinheiro and Douglas Bates bates@stat.wisc.edu

References

Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer. (section 6.4)

nlme

Linear and Nonlinear Mixed Effects Models

v3.1-152

GPL (>= 2) | file LICENCE

Authors

José Pinheiro [aut] (S version), Douglas Bates [aut] (up to 2007), Saikat DebRoy [ctb] (up to 2002), Deepayan Sarkar [ctb] (up to 2005), EISPACK authors [ctb] (src/rs.f), Siem Heisterkamp [ctb] (Author fixed sigma), Bert Van Willigen [ctb] (Programmer fixed sigma), Johannes Ranke [ctb] (varConstProp()), R-core [aut, cre]

Initial release

2021-02-03